* Man with Terminal Cancer has Extraordinary Mission
Neuralstem
Neuralstem
BY: BILL HOLLERAN
In a November article in Newsweek, science editor Sharon Begley reported on a new development in the search for a cure for amyotrophic lateral sclerosis or ALS, also known as Lou Gehrig’s disease. “Today, if all goes as planned,” Begley wrote, “the first ALS patient will receive an injection of stem cells into the upper part of his spine—the first step toward determining whether the experimental therapy can save ALS patients from dying when their motor neurons, which control muscles, become too weak to maintain breathing.”
The Rockville-based company behind the technology in this clinical trial is Neuralstem Inc. According to the company’s website, Neuralstem’s technology “enables the ability to produce neural stem cells of the human brain and spinal cord in commercial quantities.” These “regionally specific,” specialized cells are able to “integrate with, and protect, the patient’s spinal cord” because they are “already suited to the task.”
Since that first clinical step, an April University of Michigan Health System news release said, “The first published results from an early-stage clinical trial show that spinal cord stem cells can be delivered safely into the spines of patients with the condition commonly known as Lou Gehrig’s disease, opening the door for further research on this innovative approach.”
What role does innovation play at Neuralstem? “Innovation is what Neuralstem is all about,” said CEO and President Richard Garr. “Normal stem cell technology pushes cells to act like spinal cord and other cells in the central nervous system. But they are not quite the real thing.”
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“This is a completely different, and better, generation of neural cell technology,” he said. “It opens a unique window on the central nervous system.” Garr says innovation is strategically important at Neuralstem because “we only treat fatal or incurable diseases.” In addition to ALS, according to the company’s website, Neuralstem is also targeting central nervous system conditions including spinal cord injury, ischemic spastic paraplegia and chronic stroke.
Another innovation made possible by Neuralstem’s technology is the discovery of what Garr calls “an entirely new class of drugs to treat depression.” According to Garr, “Because our physiologically relevant cells already have the information they need to grow up to what they are supposed to become, we can put them in a petri dish and treat them with toxins. Then drugs can be applied to see how these compounds will interact with the neurons.” Thanks to this discovery, “we are able to test thousands of compounds on these cells.”
As a business, not a lab, said Garr, “being innovative is all about discovering new therapeutic products and creating drugs that can meaningfully improve the quality of life in patients with incurable diseases.” When it comes to stimulating innovation at Neuralstem, Garr said, “We bring a start-up sense of urgency to everything we do. When you are in the business of developing products for patients who are going to die, the sense of urgency is heightened. Our job is to find cures. That’s a strong enabler of innovation.”
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* Man With Cancer Chases 50-In-50 Marathon Goal In Alaska
Man With Cancer Chases 50-In-50 Marathon Goal In Alaska
Kevins Wells has the story of a man who is battling cancer mile-by-mile and state-by-stat…
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Go to this link and click on the video. “Man with Cancer. . . .”
* Mayor’s Marathon Taking Place This Weekend
http://www.alaskapublic.org/
Mayor’s Marathon Taking Place This Weekend
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The 39th Mayor’s Marathon held near summer solstice every year attracts thousands of visitors to Anchorage. This Saturday the organizers of the road race expect 4,300 runners to tackle the course through Anchorage, including one man with an extraordinary story.
* Mayor’s brings UAA’s Kenyan Connection full circle
Anchorage Daily News
Mayor’s brings UAA’s Kenyan Connection full circle
By DOYLE WOODY
Anchorage Daily News
Published: June 21st, 2012 11:38 PM
http://www.adn.com/2012/06/21/2515318/mayors-brings-uaas-kenyan-connection.html
The man whose email inquiry years ago sparked the dynamic Kenyan Connection for UAA’s cross-country and track programs could prove a pivotal player at the head of the
In the early 2000s, Solomon Kandie, an elite Kenyan steeplechaser at Tulane University, emailed Michael Friess to see if the Seawolves’ running coach might be interested in recruiting Kandie’s younger brother, David Kiplagat. Friess was intrigued and — long story short — pursued the offer.
“A year, year and a half later, David was here,” Friess recalled. “That really started it all.”
Kiplagat became an All-America runner for UAA. He was the forerunner of a wave of Kenyan men and women runners who have helped UAA become a force in Division II cross country and track, and proved to be excellent students and supportive teammates.
Kiplagat last year went after the course record at Mayor’s. Through 22 miles, he was on pace to threaten Michael Wisniewski’s 2009 standard (2:22:29) and seize a $5,000 prize for the record. He faltered in the late going, yet still won handily — his 2:30:52 put him nearly 16 minutes ahead of the runner-up.
Now Kiplagat is ready for another attempt at the record and the $5,000 reward, and Kandie, an accomplished marathoner, will also be in the field as the brothers chase Wisniewski’s record.
“Their plan is to go after the mark, work with each other and try to roll the record,” said Friess, the Mayor’s race director who held the course record for 22 years before Wisniewski cracked it. “I think (Kiplagat’s) in better shape than last year. You know how it is. If it clicks, if the weather’s right, he could do it.”
Kandie, who lives in Albuquerque, N.M., owns a marathon personal best of 2:17:23, which he clocked while finishing seventh in the Sacramento International Marathon in 2011. Earlier this year, he ran 2:22:23 to finish third in the Mississippi Blues Marathon.
A $5,000 prize is also available for breaking the women’s course record — best of luck with that. Chris Clark’s 2:38:19 in 2002 remains 11 minutes faster than any other woman has ever run in race history, and it looks like the 2000 Olympian’s record could stand for ages.
“Until our children are old,” Friess said.
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The top Alaska man and woman in the marathon earn two round-trip tickets from Alaska Airlines.
More than 4,000 runners are expected to compete in the five races folded into Mayor’s — besides the marathon and half-marathon, there is also a marathon relay, a 5.6-miler and 1.6-mile Youth Cup. As of Wednesday, the race featured entrants from 48 states and 16 countries.
Mayor’s offers a unique course for the marathon — 70 percent paved trails and 30 percent unpaved trails. A seven-mile stretch of rolling hills on “tank trails” along the base of the Chugach Range is a scenic, and demanding, section of the course. Also, moose sightings and the occasional bear sighting have occurred in past races.
Like many big running races, Mayor’s has developed into a platform for causes. This year, at least eight different health causes are represented, some for which runners elicit donations or pledges to support non-profits.
Because this is Alaska, Mayor’s has also developed into a destination race, a chance to visit or check a box on a runner’s list of goals.
So it is that Don Wright of Lake Elmo, Minn., is here to cross off another state on his quest to run a marathon in all 50 states. Alaska marks his 45th state — he’s got the remaining five scheduled later this year — and Mayor’s will be his 64th marathon overall.
Wright, 71, an attorney who does computer consulting, is a unique potential member of the 50 States Marathon Club. He runs with multiple myeloma, an incurable blood cancer he was diagnosed with nine years ago.
As part of a study at the Mayo Clinic, Wright takes one pill a day of pomalidomide and thus can avoid chemotherapy, which would leave him too sick to train.
“I’m the beneficiary of modern innovation and technology,” Wright said. “For me, it’s literally saving my life.”
He runs for cancer charities — Team Continuum and Tackle Cancer Foundation — that support cancer patients and their families.
Wright said he also runs to raise awareness that, while he is fortunate to be part of a study of pomalidomide, other cancer patients do not have access to such options.
“We need a better system in our country for people who are dying,” Wright said
Read more here: http://www.adn.com/2012/06/21/2515318/mayors-brings-uaas-kenyan-connection.html#storylink=cpy
* 71 Year Old Cancer Survivor Don Wright Has A Goal Of Running A Marathon In All 50 States
Read the full story and see video by clicking here.
71 Year Old Cancer Survivor Don Wright Has A Goal Of Running A Marathon In All 50 States
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71 year old cancer survivor Don Wright has a goal of running a marathon in all 50 states. So far he’s run in 44 states and he’ll make it 45 states next Saturday when he runs a marathon in Anchorage, Alaska. He runs for two charities Team Continuum and Tackle Cancer. Photojournalist John Gross has his story. To watch it click on the video box above.